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All photographs are courtesy of the Wellcome Trust Medical Photographic Library, except as follows: cover and page 10, respiratory syncytial virus, page 2, spma bifida, page 7. girl with inhaler, page 23, blue asbestos fibres, page 55. pnon fibrils Science Photo Library page 3, Ftg 1.1 The anencephalic mummy from Hermopolis Drawing by Powers 1978, after Samt-Hilaire 1826 ; from Epidemiology of Anencephalus and Spma Bifida by J Mark Elwood and j Harold Elwood 1980 ; J Mark Elwood and J Harold Elwood 1980 by permission of Oxford University Press; page 4, developing mouse brains A Copp. with permission from Oxford University Press. Hum Mol Genet 9: 575-581 page 1 3. demonstrating condom use, page 15, mother with AIDS and her children, page 17, rural AIDS awareness lecture Panos Pictures ; , page 14. pregnant woman The Telegraph Colour Library page 16. young woman and child WHO Photo Library courtesy ofT Kelly Wellcome Trust Tropical Medicine Resource page 26, Francois Nosten and infant, page 27, worker taking blood Wellcome Trust Units, South-East Asia Wellcome Trust Tropical Medicine Resource page 29, malaria parasite WHO Trammg for Control of Tropical Diseases Wellcome Trust Tropical Medicine Resource page 21. asbestos equipment, page 22. manufacturing asbestos suits, page 23, asbestos protest Hutton Getty Picture Collection page 30, brain images P Goadsby page 31, retinas D Sargan page 48. Adrian Bird K Brame ; . Cover image: Respiratory syncytial virus: a common cold virus that can cause dangerous infections in infants and the elderly, and has been implicated in the development of asthma. Comments on The Wellcome Trust Review are welcomed and should be sent to: Publishing Manager Publishing Department The Wellcome Trust 210 Euston Road London NW1 2BE Fax: + 44 0 ; 207611 8242 E-mail: publishing wellcome.acuk The Wellcome Trust Review is distributed via a mailing list held in the Marketing Department of the Wellcome Trust. If you would like to be added to this list, or if you have a colleague who would like to receive The Wellcome Trust Review, please contact Lucy Evans at the address below. The Wellcome Trust is a registered chanty, no. 210183 Trustee: The Wellcome Trust Limited Registered in England, no. 2711000 Registered office: 183 Euston Road, London NW1 2BE First published by the Wellcome Trust, 2000 The Trustee of the Wellcome Trust, London. All rights reserved No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any shape or form by any means electronic, mechanical, photocopying, recording or otherwise without the prior permission of the Wellcome Trust ISBN 1 841290 19 X The Wellcome Trust 183 Euston Road London NW1 2BE Tel: + 44 0 ; 7611 8888 Fax: + 44 0 ; 207611 8545 E-mail Marketing ; : marketing wellcome.acuk E-mail General information ; : rontact wellcome ac uk Web: ww wellcome.ac. Adverse reactions ziac bisoprolol fumarate h 25 mg is well tolerated in most patients. Branimir Brankov - Merck & Co and PBIRG President Dan Fitzgerald - GfK V2 Rob Haynes - Schering Plough Pia Nicolini - Brintnall & Nicolini Wayne Phillips - Double Helix Development Mandy Ilic - Pfizer Erich Wiegand - ADM Nora Cashion - Altana Pharma Telecalls have already taken place and information gathered from many relevant groups - particularly Drug Safety departments in pharma companies. The aim is to draft guidelines for review by the members and there will be further discussions held at the IMM in February 2007. Thanks also to those who have also volunteered to assist the Working Party - we may well call upon you at some point for input. Any questions please contact Allan Bowditch allan.bowditch abconsultingintl All the presentations from the Athens Conference are available on the EphMRA web site ephmra page 1432. Late in pregnancy, prior to the onset of labor, a fetal monitor may be used to determine the well-being of the baby and to help decide when a fetus should be delivered. This is most frequently used if a baby is past due or there are complicating medical conditions in the mother, such as high blood pressure, Rh disease, bleeding or kidney disease. It is also helpful in evaluating a fetus who is not growing properly, or whose fetal movement has decreased. The non-stress test NST ; is used to evaluate fetal heart rate patterns, especially during fetal movements. Increases in fetal heart rate are reassuring of fetal well-being, and the test is called reactive. A non-reactive test can be caused by medication or a sleeping fetus, and may require further testing. The contraction stress test CST ; will allow us to evaluate how the fetal heart reacts to uterine contractions. Certain fetal heart tracing characteristics occur in both healthy and unhealthy fetuses. The uterine contractions can be induced by a medication called oxytocin which is administered intravenously. The "stress" created by the contractions may reveal that the fetus is receiving a marginal blood and oxygen supply, for example, maxzide. XalaTaN . XYlocaiNe . See lidocaine inj ZaDiToR . ZaNTac . See ranitidine ZaRoNTiN . See ethosuximide ZeBeTa . See bisoprolol ZelNoRM . ZesToReTic . e lisinopril hydrochlorothiazide ZesTRil . See lisinopril ZeTia . Zoac . 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