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A locate resource request is an example of an asynchronous communication: its execution consists in the forwarding of the request to other servers. A response can be sent or not, depending on the presence of the queried resource in that node. In this model, typically, the requester is collecting the responses it receives if any ; in a certain amount of time. Server: a server is a specialization of an abstract server. The specialization lies in the fact that the abstract part of the interface gets assigned a behavior which depends on the protocol to be implemented. A server node is the abstraction of a single machine hosting the two daemons that make up a single xrootd node, i.e., the olbd daemon and the xrootd daemon, plus a disk system containing the data pertinent to that node. This model considers a simplification of all the possible configurations and behaviors of a single xrootd node. The main simplifications are: a node can subscribe to only one node [8]. i.e., the possible topologies are only tree-based; a server node cannot receive queries to answer and or propagate ; from more than one other server node; a server node is a single machine doing that job only; a server node contains a single disk subsystem, which is an instance of a Disk System class. The purposes of a server node are: permitting the access to the resources contained in its disk subsystem participating in the distributed resource location mechanism. A server will: answer if necessary ; to the location information requests a msg locate async Message ; coming from the server where it subscribed to; propagate if necessary ; the location information requests a msg locate async Message ; to the servers which subscribed to it; receive the location information messages a msg location async Message ; coming from the servers which subscribed to him, and: update its internal information about remote resources; backpropagate if necessary ; the location information messages to the server where it subscribed to. Disk System: a disk system whose interface is shown in Table 5.3 ; is a simulation process which simulates the behavior of the storage system belonging to a single server. A disk system can be requested to simulate the asynchronous read or write of a block of data. A disk system is able to perform the requested operations in an autonomous way. It collects all the pending requests in a queue, and simulates the. 11-HYDROXYSTEROID DEHYDROGENASE 11HSD ; IN THE HEART OF NORMOTENSIVE AND HYPERTENSIVE RATS K. Mazancov1, 2, I. Miksk1, J. Pcha1 1 Institute of Physiology, Czech Academy of Science and 2Second Faculty of Medicine, Charles University, Prague, Czech Republic Recent studies have shown that not only increased blood pressure but also various humoral factors including corticosteroids play a role in the cardiac fibrosis and hypertrophy secondary to hypertension. The effects of glucocorticoids and mineralocorticoids on the target cells depend on coexpression of glucocorticoid GR ; and mineralocorticoid receptors MR ; and 11HSD which catalyzes interconversion of glucocorticoids to 11-oxo metabolites that have different affinities for GR and MR. The type 2 isoform 11HSD2 ; converts glucocorticoids to their inactive 11oxo metabolites and thus protects MR from binding of glucocorticoids. In contrast, 11HSD type 1 11HSD1 ; operates in vivo in an opposite direction and increases local concentration of glucocorticoids. To ascertain whether cardiac hypertrophy during hypertension is associated with changes of 11HSD we performed real-time RT-PCR analysis and enzyme activity measurement of 11HSD1 and 11HSD2 in two genetic models of hypertension: spontaneously hypertensive SHR ; and Dahl salt-sensitive DS ; rats and their normotensive counterparts WistarKyoto WKY ; and Dahl salt-resistant DR ; rats. The relative heart weights of Dahl rats kept on high-salt diet 8 % NaCl ; was higher in DS than in DR rats. Similarly, heart weight was higher in SHR than in WKY rats. 11HSD2 mRNA abundance was lower in SHR than WKY rats but not between DS and DR rats. In contrast, 11HSD1 mRNA expression was similar in SHR and WKY rats but was lower in DS than in DR rats. 11HSD1 activity studies correlated with 11HSD1 mRNA expression. In conclusion, the cardiac metabolism of glucocorticoids varies between normotensive and hypertensive rats. These findings open the possibility for changes in autocrine and paracrine actions of corticosteroids during cardiac remodelling. Supported by grant GA UK 44 2002 C 2.LF to K.M. Hydrodiuril drug Glyset Halcion * triazolam ; Humalog Humulin Hydrofiuril * hydrochlorothiazide ; Hytrin * terazosin ; Imdur * isosorbide mononitrate ; Imitrex Inderal * propranolol ; Inderal LA Indocin, SR * indomethacin, SR ; Intal Inh. 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