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Lzheimer's disease AD ; is a common condition that affects mostly people over age 65 but can happen as early as age 40. It occurs equally in men and women and leads to loss of short-term memory while long-term memory is preserved or is even better than normal. Treatments that are currently available include five prescription drugs, of which four are in common use, and herbal and vitamin therapies which may have value but remain controversial. The prescription drugs fall into two classes. The first were the cholinesterase inhibitors, drugs which prevent the breakdown of acetylcholine, a chemical messenger in the brain important to memory and thinking. Acetylcholine levels were observed to be low in the brains of patients with AD in the 1970s. The first drug approved in 1993 was Cognex tacrine ; , which gave patients a mental boost but unfortunately caused liver damage which limited its use. The second drug approved in 1997 was Aricept donepezil ; , which does not affect the liver and can have dramatic effects in about a third of patients. The third drug approved in 2000 was Ex3lon rivastigmine ; , which adds a second enzyme inhibiting effect which makes it quite potent in improving memory and cognition. The fourth drug approved in 2001 was Reminyl, now renamed Razadyne galanthamine ; , which actually was found in daffodils and so an herbal version exists. Razadyne ER is a once-daily version of the drug which became available this year. The second class of drugs for AD are the selective NMDA antagonists. At this time the only approved drug in this class is Namenda memantine ; , which works in a complementary way to the first class, so a drug in that class like Exelkn or Aricept is often combined with Namenda for better effect. Namenda produces improvement in cognition and memory which is synergistic with the effect of a cholinesterase inhibitor, and can also work on its own. There is reason to believe that Namenda may have anti-amyloid effects which could slow down the course of the disease, but this has not been proven in patients. 225 Stroke in Young Adults: Risk Factors, Subtypes and Outcome Experience from the St. Luke's Medical Center Stroke Data Bank.

Sarah Eichorn Exeelon 2301 Market Street S12-3 Philadelphia, PA 19103 Fedex Address: 2301 Market Street S12-3 Philadelphia, PA 19103 Ron Hart Manager, Electric Market Policy Fairless Energy, LLC 5000 Dominion Blvd. 3-SE Glen Allen, VA 23059 Fedex Address: 5000 Dominion Blvd. 3-SE Glen Allen, VA 23059 William C. Moll Staff Business Analyst FirstEnergy Corporation 76 South Main St Akron, OH 44308 Fedex Address: 76 South Main St Akron, OH 44308 David E. Hamilton Sr. Forecast Analyst Old Dominion Electric Cooperative P.O. Box 2310 Glen Allen, VA 23058-2310 Fedex Address: 4201 Dominion Blvd. Innsbrook Corporate Center Glen Allen, VA 23060. Strong growth continues because of the excellent tolerability and efficacy of these medicines!


Overdose of generic for exelon : any medication taken in excess can have serious consequences and floxin. The dishwasher company that blames the cleanser company, and vice-versa. You end up in the middle of a tennis game. You must work with a company that can show close relationships with the detergent companies - we do, and if necessary, we get them to come on site with us to work out any problems between us." "What really annoys us in this trade is cheap products. We don't mind cheap products being on the market, but we object to them being sold as the equivalent to a product like ours. Sorry - they're patently not the same thing." There are hazards which can cause annoyance out of all proportion. "We make baskets with a tilt mechanism. This is because some glasses and cups have little indentations designed into the base, which often retain water after the wash. A couple of dozen cups all spilling a few millilitres of water makes a big mess! "So our tilt allows the water to run away. We will also ask for samples of the glasses or cups being used, so we can make the ideal basket to suit. "A 'soft-start' is a mechanism which means the wash does not start at full power. If you are using a cheap basket in which the glasses or cups are not separated from each other, then allowing the full force of the water in will drive the items against each other, and you'll get damage. It is almost certain that cheaper machines will not feature a soft start." Although there are leasing arrangements, the Meiko machines which are in the majority of chain coffee-bars retail at between 1, 700 and 2, 500. "You can certainly buy cheaper, " says Michael Boyd, "but please beware of the hidden extras, and of any quotation which says 'subject to site survey'. "We have seen `extras', which the buyer is told are absolutely necessary, that push the price of a machine up by 25 per cent. "Just don't buy on price alone. If a supplier's price seems too good to be true - it probably is!" meiko-uk. Release of the body is appropri ate. Medical devices may be removed and fluoxetine, for example, exelon sales. Would like any info on the drug.

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Double-blind, parallel-group, placebo-controlled study. Lancet. 2006; 367: 1057-1065. Csemansky JG, Wang L, Miller JP, et al. Neuroanatomical predictors of response to donepezil therapy in patients with dementia. Arch Neurol. 2005; 62: 1718-1722. Donepezil Aricept ; package insert. Teaneck, NJ: Eisai, Inc. 44. Rivastigmine Ex4lon ; package insert. Summit, NJ: Novartis Pharmaceuticals. 45. Reisberg B, Doody R, Stoffler A, et al. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med. 2003; 348: 1333-1341. Wimo A, Winblad B, Stoffler A, et al. Resource utilisation and cost analysis of memantine in patients with moderate to severe Alzheimer's disease. Pharmacoeconomics. 2003; 21: 327-340. Bullock R. Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: the evidence to date. Alzheimer Dis Assoc Disord. 2006; 20: 23-29. Peskind E, Potkin SG, Pomara N, et al. Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial. DUONEB DURAGESIC 12mcg DYNACIRC CR econazole nitrate * EFFEXOR XR ELESTAT ELIDEL 30gm ELIDEL 60gm, 100gm ELIGARD EMADINE EMEND EMTRIVA ENABLEX enalapril maleate * enalapril maleate hctz * ENBREL enpresse * EPIPEN, -JR. errin * ERTACZO erythrocin stearate erythromycin base * erythromycin ethylsuccinate erythromycin w sulfisoxazole * erythromycin * ESTRADERM estradiol transdermal patch * estradiol * ESTRASORB ESTRATEST, -H.S. M ; ESTROGEL estrogen-methyltestosterone * estropipate * ESTROSTEP FE etodolac * EVISTA EXELDERM EXELON FACTIVE famotidine * FAMVIR FAST TAKE FAST TAKE MONITORING SYSTEM felodipine * FEMARA FEMHRT FEMTRACE fentanyl * fexofenadine * FINACEA finasteride flecainide acetate * FLOMAX FLOVENT HFA FLOXIN OPHTH DROPS ; fluconazole * fludrocortisone acetate * FLUMADINE flunisolide nasal fluocinonide * fluoxetine hcl * flurazepam hcl and isordil.
Guidelines for the diagnosis and management of AD are available.1, 5 A definitive diagnosis of dementia is the first step in management. The nonpharmacological and pharmacological management of the amnesic elements and the neuropsychiatric symptoms are discussed below. NONPHARMACOLOGICAL MANAGEMENT There is an evolving concept of the "at risk brain" with parallel development of "brain protection strategies" wearing seat belts, avoiding boxing, caring for one's arteries blood pressure, lipids etc. ; .12 For patients with dementia, general health maintenance activities such as - exercise, control of hypertension, influenza vaccination, dental hygiene and assessment of eyeglass wear and hearing aids should be encouraged.13 The following improve functional performance: low lighting levels, music and simulated nature sounds beneficial particularly at meal and bathing times ; , graded assistance, positive reinforcement and intensive multi-modality group training.1, 3 Specific areas of concern for patients with mild to moderate dementia are driving, cooking, and wandering. Forgetfulness, poor insight and judgement, easy distractibility, and problems following directions add to the difficulties for patients and their carers. Six-monthly review of dementia severity and appropriateness of continued driving should be performed. The risk of driving-related-accidents is the same in the first year after diagnosis as for drivers of all ages, but increases significantly thereafter.12, 14 Areas of concern for those with severe dementia are urinary incontinence, falls and aggressive behaviour. Urinary incontinence may be reduced by behaviour modification, scheduled toileting and prompted voiding. PHARMACOLOGICIAL MANAGEMENT A definitive diagnosis by a specialist in this area is recommended before commencing drug therapy. Commonly used scales in clinical trials to assess dementia severity include the Clinician's InterviewBased Impression of Change with Caregiver input CIBIC-plus ; , the Alzheimer's Disease Assessment Scale cognitive subscale ADAS-cog ; and the more widely used Mini Mental State Examination MMSE ; .3 In untreated patients, the ADAS-Cog has a typical rate of increase reflecting clinical deterioration ; of 7 points a year.3 In clinical trials, a 4-point decrease is equivalent to reversing the symptoms of the disease by approximately six months, and a 7-point decrease is equivalent to a one-year reversal.3 Cholinesterase inhibitors: Cerebral production of choline acetyl transferase is reduced in dementia, resulting in impaired cholinergic function. Cholinesterase inhibitors CIs ; inhibit cholinesterase at the synaptic cleft and increase cholinergic transmission. Three CIs are licensed in Ireland for the treatment of mild to moderate AD: donepezil Aricept ; , rivastigmine Exelon ; and galantamine Reminyl ; . Efficacy: Clinical trials of CIs15-17 have shown changes of 2.5-3.5 points on the ADAS-Cog and differences of 0.3-0.5 on the CIBIC-Plus. Three times as many patients receiving a CI had a 7-point improvement on the ADAS-Cog versus placebo and approximately twice as many patients who received a CI had a 4-point improvement on the ADAS-Cog versus placebo.3, 18 Positive secondary endpoints in the.
12 ; PATENT APPLICATION PUBLICATION 19 ; INDIA 22 ; Date of filing of Application: 27 02 2004 ; Title of the invention: " PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ASTHMA" 51 ; International classification: A61K 31 00 31 ; Priority Document No: 60 315, 386 ; Priority Date: 28 8 2001 ; Name of priority country: USA 87 ; WIPO No. : PCT US02 27336 61 ; Patent of addition to Application No. : Filed on: 62 ; Divisional to Application No.: Filed on and letrozole.

The plant would need to apply by april or else risk shutdown if the application is pending when the current 40-year license expires in 200 lobbying groups opposed to continued generation at the plant said kennedy may help exelon win support in trenton, but are hopeful that lawmakers will consider public safety, not political connections, when taking a position. Crocker et al. Calpains and Parkinson's Disease Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WG, Dawson VL, Dawson TM, Przedborski S 1999 ; Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 5: 14031409. Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, Dawson TM 1999 ; Poly ADP-ribose ; polymerase activation mediates 1-methyl-4phenyl-1, 2, 3, MPTP ; -induced parkinsonism. Proc Natl Acad Sci USA 96: 5774 5779. Markgraf CG, Velayo NL, Johnson MP, McCarthy DR, Medhi S, Koehl JR, Chmielewski PA, Linnik MD 1998 ; Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats. Stroke 29: 152 158. Martorana A, Fusco FR, Picconi B, Massa R, Bernardi G, Sancesario G 2001 ; Dopamine denervation induces neurotensin immunoreactivity in GABAparvalbumin striatal neurons. Synapse 41: 360 362. Mattson MP, LaFeria FM, Chan SL, Leissring MA, Shepel PN, Geiger JD 2000 ; Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci 23: 222229. Matuszewich L, Yamamoto BK 1999 ; Modulation of GABA release by dopamine in the substantia nigra. Synapse 32: 29 36. McMahon A, Wong BS, Iacopino AM, Ng MC, Chi S, German DC 1998 ; Calbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells. Brain Res Mol Brain Res 54: 56 63. Melloni E, De Tullio R, Averna M, Tedesco I, Salamino F, Sparatore B, Pontremoli S 1998 ; Properties of calpastatin forms in rat brain. FEBS Lett 431: 5558. Merali Z, Piggins H 1990 ; Effects of dopamine D1 and D2 receptor agonists and antagonists on bombesin-induced behaviours. Eur J Pharmacol 191: 281293. Mochizuki H, Hayakawa H, Migita M, Shibata M, Tanaka R, Suzuki A, Shimo-Nakanishi Y, Urabe T, Yamada M, Tamayose K, Shimada T, Miura M, Mizuno Y 2001 ; An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease. Proc Natl Acad Sci USA 98: 10918 10923. Mouatt-Prigent A, Karlsson JO, Agid Y, Hirsch EC 1996 ; Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? Neuroscience 73: 979 987. Nakamura K, Bindokas VP, Marks JD, Wright DA, Frim DM, Miller RJ, Kang UJ 2000 ; The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol Pharmacol 58: 271278. Nestler EJ, Kelz MB, Chen J 1999 ; DeltaFosB: a molecular mediator of long-term neural and behavioral plasticity. Brain Res 835: 10 17. Palkovits M, Brownstein MJ 1988 ; Maps and guide to microdissection of the rat brain. New York: Elsevier. Paschen W, Frandsen A 2001 ; Endoplasmic reticulum dysfunction--a common denominator for cell injury in acute and degenerative diseases of the brain? J Neurochem 79: 719 725. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH 1999 ; Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402: 615 622. Perez-Otano I, Mandelzys A, Morgan JI 1998 ; MPTP-parkinsonism is accompanied by persistent expression of a delta-FosB-like protein in dopaminergic pathways. Brain Res Mol Brain Res 53: 4152. Przedborski S, Jackson-Lewis V 2000 ; ROS and Parkinson's disease: a view to a kill. In: Free radicals in brain pathophysiology Poli G, Cadenas E, Packer L, eds ; , pp 273290. New York: Marcel Dekker. Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, Dawson TM 1996 ; Role of neuronal nitric oxide in 1-methyl-4-phenyl1, 2, 3, MPTP ; -induced dopaminergic neurotoxicity. Proc Natl Acad Sci USA 93: 4565 4571. Przedborski S, Jackson-Lewis V, Naini AB, Jakowec M, Petzinger G, Miller R, Akram M 2001 ; The parkinsonian toxin 1-methyl-4-phenyl-1, 2, 3, MPTP ; : a technical review of its utility and safety. J Neurochem 76: 12651274. Przedborski S, Jackson-Lewis V, Vila M, Wu du C, Teismann P, Tieu K, Choi DK, Cohen O 2003 ; Free radical and nitric oxide toxicity in Parkinson's disease. Adv Neurol 91: 8394. Radke JM, Owens MJ, Ritchie JC, Nemeroff CB 1998 ; Atypical antipsy and levocetirizine.
We will continue to work closely with the fda as the agency finalizes its review of eexlon for the treatment of parkinson's patients with dementia. Over the gas fire erupts at fort worth power plant - apr 23, 2007 dallas morning news subscription ; , texas department of transportation cameras on nearby interstate 820 showed the flare at the exeelon corp and lopid and exelon.
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Department of Medicine, London Health Sciences Centre; Department of Pharmacology and Toxicology, University of Western Ontario, Lawson Health Research Institute, London, Ontario Correspondence: Dr David G Bailey, Department of Medicine, London Health Sciences Centre, Victoria Campus, 375 South Street, London, Ontario N6A 4G5. Telephone 519-685-8500 ext 75699, fax 519-432-7367, e-mail david.bailey lhsc.on Accepted for publication October 3, 2002 Can J Clin Pharmacol Vol 9 No 4 Winter 2002 191. Exelon also identified an alternative site for a texas power plant, in victoria county , about 128 miles southwest of houston, if the matagorda site is for some reason deemed unsuitable.

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Retrieval, and in the case of donor egg cycles, unless the sexually intimate partner's sperm has been frozen and quarantined prior to use in ART. Participants in the ART Program may wish to seek the advice of an attorney knowledgeable in the field of reproductive technology before deciding whether to donate embryos, in order to receive current information regarding any potential legal risks that may be involved in such donation. Participants who have a strong desire either to have or not to have embryos donated in the event that they cannot make such a decision for themselves should present such information to the ART Program staff in writing prior to having the embryos frozen. To ensure that they can donate, they may also wish to be tested for infectious disease at the time of egg retrieval. e ; Donation for Research: Upon written request and agreement to sign a consent to donate form, participants may donate their embryos for research. Research embryos will at no time be transferred to recipients for use in establishing a pregnancy. 2. Required Consents or Approvals Before Frozen Embryos are Used for any Purpose. As a general rule, the ART Program staff will not offer a frozen embryo to a donee, release it to another physician or facility or intentionally thaw it and allow it to die without obtaining the prior written consent of the participants. However, the ART Program staff may take action with respect to an embryo including removing it from storage and allowing it to die ; , without having first obtained the consent of the participants in situations where the embryo has been "abandoned." Abandonment will be considered to have occurred in the following circumstances: a ; the embryo has been stored at DHMC for a total of 5 years and the participants have been unable or unwilling to make arrangements to transfer the embryos to a long term storage facility; b ; the embryo has been frozen for one year or more and the participants have not responded within 30 days to a certified letter sent to the last address known to the ART Program requesting their consent to a disposition of the embryo. Note: The time frame for storage of over one year must be confirmed in writing by the participants. Storage times may be extended up to 5 years for conditions such as a pregnancy established in the original transfer or a medical condition which temporarily prevents pregnancy; c ; non-payment of storage fees or other hospital bills. Failure to pay storage fees or failure to make appropriate arrangements with the Business Office to pay preexisting bills, may result in discard of stored embryos.

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Mr. Philip G. Harris President and Chief Executive Officer PJM Interconnection Valley Forge Corporate Center 955 Jefferson Avenue Norristown, PA 19403-2497 Dear Phil: I writing in response to your request for comments on PJM's 2007 Strategic Report published on April 2, 2007. Attached is the Exelon companies' ComEd, PECO Energy, and Exelon Generation, collectively Exelon ; detailed response to the 28 recommendations contained in the Report. A cross-functional team led by me, and Ian McLean, Executive Vice President and President, Exelon Power Team, coordinated our response. Sue Ivey has requested to represent Exelon on May 2, 2007, at the PJM General Session to discuss our views on the Strategic Initiative. Let me say at the outset that we at Exelon appreciate the open process that PJM is using to engage stakeholders in the development of the Strategic Plan. For example, we are very pleased that PJM heard and reacted appropriately to the strong opposition to the idea of splitting its operations into two parts a reliability function and a market function. Exelon also applauds PJM for its strong commitment to the advancement of demand-side management programs. Regarding markets, we believe that PJM is recommending the right approach to the development of new market products voluntary and driven by the needs of market participants. In the area of Board communications, Exelon is satisfied that the improvements already made conducting open stakeholder forums on critical issues, for example ; go far enough in improving the visibility and accessibility of the PJM Board. We even caution, as you will see in our detailed comments, that some of the recommended activities would unduly burden the Board and may cause unnecessary expenditures. We continue to recognize the cumbersome, inefficient nature of the existing governance process and remain committed to support efforts to streamline it with the goal of making the process more effective and efficient. Having said that, Exelon has serious concerns about the PJM's proposed development efforts regarding the "Smart Grid" initiative. We appreciate and support the recommendation in the PJM Strategic Report for PJM and PJM market participants to use advanced technologies and two-way communications to improve grid and market operations. Patients should inform their doctor if they are taking any medication. DOCKET NO. D-69-210 CP FINAL ; Revision 11 ; DELAWARE RIVER BASIN COMMISSION Exelon Generation Company, LLC Mine Pool Withdrawal and Stream Flow Augmentation Demonstration Project Limerick Township, Montgomery County and New Castle Township, St. Clair Borough, and Norwegian Township, Schuylkill County, Pennsylvania PROCEEDINGS This is an application submitted by Exelon Generation Company, LLC Exelon ; on May 16, 2003, for an allocation of surface water and review of a stream flow augmentation demonstration project. The applicant plans to demonstrate the feasibility of using mine pool water from Wadesville Mine Pool and additional releases from reservoirs operated by the Borough of Tamaqua for stream flow augmentation during a four to six month period following approval of this application. The application was reviewed for revision of the project in the Comprehensive Plan and approval under Section 3.8 of the Delaware River Basin Compact. The Montgomery County and Schuylkill County Planning Commissions have been notified of pending action on this docket. A public hearing on this project was held by the DRBC on June 26, 2003.

Administration has the primary responsibility for implementation of the intervention program in each school. Student Service Staff will perform key roles in the implementation of intervention programs. School Staff, including all classified and certificated staff, shall be trained to recognize early symptoms of drug and alcohol misuse and understand their responsibilities in assisting with the processes of the Student Assistance Program. Core Team has the responsibility for planning, implementing and evaluating the program in its school. It will be responsible for facilitating the education awareness intervention component of the program, as well as working directly with administrators, staff, students, parents and community resources. The Core Team shall consist of a group of staff members who have a commitment and a desire to implement the Student Assistance mode. The team will range from five to seven members and shall include classroom teachers, student services staff and others. The principal will appoint one member of the team as Core Team leader. Core team members will receive specialized training in alcohol and drug abuse dependency. This can be accomplished by attending school staff inservice activities and other specialized training. Resources will be provided for staff release time and or stipends for Core Team members to meet on a regular basis. B. Student Assistance Program - Processes. The costs measured were operating costs drug acquisition costs of initial therapy, physician visit and diagnostic tests costs. In many countries, the pharmacist is registered and qualified.

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[DPSOH3UHFRQFHSWLRQ6XUYH\ The Simcoe District Health Unit surveyed its community in 1994 as part of their planned approach to increasing awareness and services around preconception and health. They found that a high proportion of those surveyed connected preconception health with improved pregnancy outcomes. Most individuals surveyed recognized that male health is also important prior to conception. About half wanted to learn more about preconception health and were prepared to make lifestyle changes. There was interest in incorporating preconception information in secondary school health education and in making preconception care available to those planning a pregnancy. Preconception literature and one-on-one interaction were strategies that appealed to the participants. The survey results helped the committee select and define interventions around preconception knowledge and behaviours. Introduction neoadjuvant medical therapy is treatment given before rather than after surgery to patients with large operable or locally advanced breast cancers. DECISION I. The Comprehensive Plan of the DRBC, as amended by Docket No. D-69-210 CP Final ; on November 5, 1975, is hereby revised as follows: 1 ; The provisions of Docket No. D-69-210 CP [attached and included as part thereof to D-69-210 CP Final ; and Revisions ; ] headed "FINDINGS", "Sources of Water Supply", "1. Schuylkill River" is revised by the addition of a new paragraph e ; on page 5, which reads as follows: e ; Water may be withdrawn from the Wadesville Mine Pool to augment Schuylkill River flows for subsequent withdrawal for consumptive use at Limerick for the proposed demonstration project described herein including use of the applicant's existing approved emergency back-up source, the Tamaqua Reservoir System in accordance with Exelon's project Demonstration Operating Plan, upon approval of such plan by the Executive Director. If any data or information indicates it necessary, the project operations shall be subject to modification by the Executive Director. For purposes of the proposed demonstration project, total augmentation from Wadesville mine pool shall not exceed 432 million gallons during any 30-day period.
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